Strategies for the design of nanoparticles: starting with long-circulating nanoparticles, from lab to clinic.
Biomater Sci
; 9(10): 3621-3637, 2021 May 18.
Article
en En
| MEDLINE
| ID: mdl-34008587
ABSTRACT
Short half-life is one of the main causes of drug attrition in clinical development, which also leads to the failure of many leading compounds and hits to become drug candidates. Nowadays, nanomaterials have been applied to drug development to address this problem. In fact, the clinical application of nanoparticles (NPs) is severely limited due to their rapid elimination by the reticuloendothelial system (RES) in vivo. In this paper, we aim to summarize representative strategies on prolonging the circulation time for bridging the gap between excellent pharmaceutics and proper half-life and encourage clinical translation.
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Base de datos:
MEDLINE
Asunto principal:
Nanopartículas
Idioma:
En
Revista:
Biomater Sci
Año:
2021
Tipo del documento:
Article