Studies on non-medicinal parts of plant materials: Triterpenes from the roots of Schisandra chinensis.
Fitoterapia
; 152: 104939, 2021 Jul.
Article
en En
| MEDLINE
| ID: mdl-34029653
ABSTRACT
Phytochemical study on a non-medicinal part of a plant material for herbal medicine, the roots of Schisandra chinensis, was conducted to isolate five new triterpenes, schinensins A-D (1-4) and 3-O-methylchangnanic acid (5), together with 21 known compounds including 10 triterpenes, one sterol, two sesquiterpenes, seven lignans, and one flavonoid. The structures of new triterpenes (1-5) were assigned on the basis of spectroscopic analyses aided with TDDFT ECD calculations. Schinensin A (1) was a dinortriterpene possessing 28-norschiartane skeleton, while schinensins B-D (2-4) were assigned as 3,49,10-disecocycloartane, 3,4-secocycloartane, and cycloartane triterpenes, respectively. In an evaluation of antiproliferative activities against human cancer cell lines, some triterpenes exhibited significant activities against human breast carcinoma MCF-7 cells as compared to the other cell lines (A549, HeLa, and RPMI8226).
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Triterpenos
/
Schisandra
/
Antineoplásicos Fitogénicos
País/Región como asunto:
Asia
Idioma:
En
Revista:
Fitoterapia
Año:
2021
Tipo del documento:
Article