Safety and mid-term surgical results of anterior urethroplasty with the tissue-engineered oral mucosa graft MukoCell® : A single-center experience.
Int J Urol
; 28(9): 936-942, 2021 09.
Article
en En
| MEDLINE
| ID: mdl-34053150
ABSTRACT
OBJECTIVE:
To assess the mid-term efficacy and safety of anterior urethroplasty using an autologous tissue-engineered oral mucosa graft (MukoCell® ).METHODS:
The data of 77 patients with anterior urethral strictures undergoing treatment with MukoCell® at a tertiary center from June 2016 to May 2019 were analyzed. Patients' characteristics, pre- and postoperative diagnostics, perioperative complications, and follow-up data were obtained. The overall stricture-free survival, outcomes of the different surgical techniques, stricture localizations, stricture length, early complications of the procedure and risk factors of recurrence were assessed.RESULTS:
The median follow-up period was 38 months (interquartile range 31-46). The overall recurrence-free rate of anterior urethroplasty using MukoCell® was 68.8%, 24 patients (31.2%) developed a recurrence of the stricture. The stricture recurrences were observed at a median of 7 months (interquartile range 3-13) only in patients with at least one previous surgery or repeated dilatations in their medical history. No oral-urethral adverse events related to the use of MukoCell® were observed, except for a urethrocutaneous fistula (1.3%) requiring reoperation.CONCLUSIONS:
Anterior one-stage urethroplasty using MukoCell® showed in our hands a mid-term success rate of up to 68.8% without significant adverse events after a median follow-up period of 38 months. This procedure might be an alternative option for long-segment urethral reconstruction.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Estrechez Uretral
/
Procedimientos de Cirugía Plástica
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Int J Urol
Asunto de la revista:
UROLOGIA
Año:
2021
Tipo del documento:
Article