Protective effect of dimethyl itaconate against fibroblast-myofibroblast differentiation during pulmonary fibrosis by inhibiting TXNIP.

Han, Yong-Yue; Gu, Xuan; Yang, Chong-Yang; Ji, Hui-Min; Lan, Yue-Jiao; Bi, Yu-Qian; Si, Rong; Qu, Jiao; Cheng, Ming-Han; Gao, Jian

Han, Yong-Yue; Gu, Xuan; Yang, Chong-Yang; Ji, Hui-Min; Lan, Yue-Jiao; Bi, Yu-Qian; Si, Rong; Qu, Jiao; Cheng, Ming-Han; Gao, Jian.

Afiliación

Han YY; The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Gu X; The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Yang CY; The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Ji HM; The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Lan YJ; The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Bi YQ; The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Si R; The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Qu J; The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Cheng MH; The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Gao J; The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.

J Cell Physiol ; 236(11): 7734-7744, 2021 11.

Article en En | MEDLINE | ID: mdl-34061990

Asunto(s)

Antifibróticos/farmacología; Proteínas Portadoras/antagonistas & inhibidores; Diferenciación Celular/efectos de los fármacos; Fibroblastos/efectos de los fármacos; Pulmón/efectos de los fármacos; Fibrosis Pulmonar/tratamiento farmacológico; Succinatos/farmacología; Tiorredoxinas/antagonistas & inhibidores; Animales; Bleomicina; Proteínas Portadoras/genética; Proteínas Portadoras/metabolismo; Línea Celular; Modelos Animales de Enfermedad; Fibroblastos/metabolismo; Fibroblastos/patología; Humanos; Pulmón/metabolismo; Pulmón/patología; Masculino; Ratones Endogámicos C57BL; Miofibroblastos/efectos de los fármacos; Miofibroblastos/metabolismo; Miofibroblastos/patología; Factor 2 Relacionado con NF-E2/agonistas; Factor 2 Relacionado con NF-E2/metabolismo; Fibrosis Pulmonar/inducido químicamente; Fibrosis Pulmonar/metabolismo; Fibrosis Pulmonar/patología; Especies Reactivas de Oxígeno/metabolismo; Tiorredoxinas/genética; Tiorredoxinas/metabolismo; Factor de Crecimiento Transformador beta1/farmacología

Palabras clave

Nrf2; TXNIP; dimethyl itaconate; fibroblast-myofibroblast differentiation; pulmonary fibrosis

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fibrosis Pulmonar / Succinatos / Tiorredoxinas / Proteínas Portadoras / Diferenciación Celular / Fibroblastos / Antifibróticos / Pulmón Tipo de estudio: Prognostic_studies Idioma: En Revista: J Cell Physiol Año: 2021 Tipo del documento: Article

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