Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus.
Mar Drugs
; 19(5)2021 May 19.
Article
en En
| MEDLINE
| ID: mdl-34069724
ABSTRACT
Three new p-terphenyl derivatives, named 4â³-O-methyl-prenylterphenyllin B (1) and phenylcandilide A and B (17 and 18), and three new indole-diterpene alkaloids, asperindoles E-G (22-24), were isolated together with eighteen known analogues from the fungi Aspergillus candidus associated with the South China Sea gorgonian Junceela fragillis. The structures and absolute configurations of the new compounds were elucidated on the basis of spectroscopic analysis, and DFT/NMR and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, the compounds 6, 9, 14, 17, 18 and 24 modulated spontaneous Ca2+ oscillations and 4-aminopyridine hyperexcited neuronal activity. A preliminary structure-activity relationship was discussed.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Aspergillus
/
Compuestos de Terfenilo
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Alcaloides Indólicos
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Antozoos
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Diterpenos
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Neuronas
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Mar Drugs
Asunto de la revista:
BIOLOGIA
/
FARMACOLOGIA
Año:
2021
Tipo del documento:
Article