Behçet's Disease-Do Microbiomes and Genetics Collaborate in Pathogenesis?
Front Immunol
; 12: 648341, 2021.
Article
en En
| MEDLINE
| ID: mdl-34093536
ABSTRACT
Behçet's disease (BD) is a multisystem autoinflammatory condition characterized by mucosal ulceration, breakdown of immune privilege sites and vasculitis. A genetic basis for BD has been described in genome-wide and validation studies. Similarly, dysbiosis of oral and gut microbiomes have been associated with BD. This review will describe links between genetic polymorphisms in genes encoding molecules involved in gut biology and changes seen in microbiome studies. A potential decrease in bacterial species producing short chain fatty acids linked to mutations in genes involved in their production suggests a potential therapy for BD.
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Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Síndrome de Behçet
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Predisposición Genética a la Enfermedad
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Polimorfismo de Nucleótido Simple
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Disbiosis
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Microbioma Gastrointestinal
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Front Immunol
Año:
2021
Tipo del documento:
Article