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Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.
Garcia, Laura Ramos; Tenev, Tencho; Newman, Richard; Haich, Rachel O; Liccardi, Gianmaria; John, Sidonie Wicky; Annibaldi, Alessandro; Yu, Lu; Pardo, Mercedes; Young, Samuel N; Fitzgibbon, Cheree; Fernando, Winnie; Guppy, Naomi; Kim, Hyojin; Liang, Lung-Yu; Lucet, Isabelle S; Kueh, Andrew; Roxanis, Ioannis; Gazinska, Patrycja; Sims, Martin; Smyth, Tomoko; Ward, George; Bertin, John; Beal, Allison M; Geddes, Brad; Choudhary, Jyoti S; Murphy, James M; Aurelia Ball, K; Upton, Jason W; Meier, Pascal.
Afiliación
  • Garcia LR; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK. Laura.ramosgarcia@icr.ac.uk.
  • Tenev T; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Newman R; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Haich RO; Department of Biological Sciences, Auburn University, Auburn, AL, USA.
  • Liccardi G; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • John SW; Institute of Biochemistry I, Medical Faculty, Joseph-Stelzmann-Str. 44, University of Cologne, Cologne, Germany.
  • Annibaldi A; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Yu L; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Pardo M; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany.
  • Young SN; Functional Proteomics Group, The Institute of Cancer Research, London, UK.
  • Fitzgibbon C; Functional Proteomics Group, The Institute of Cancer Research, London, UK.
  • Fernando W; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Guppy N; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Kim H; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Liang LY; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Lucet IS; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Kueh A; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Roxanis I; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Gazinska P; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Sims M; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
  • Smyth T; Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
  • Ward G; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Bertin J; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
  • Beal AM; Astex Pharmaceuticals, Cambridge, UK.
  • Geddes B; Astex Pharmaceuticals, Cambridge, UK. tomoko.smyth@astx.com.
  • Choudhary JS; Astex Pharmaceuticals, Cambridge, UK.
  • Murphy JM; Innate Immunity Research Unit, GlaxoSmithKline, Collegeville, PA, USA.
  • Aurelia Ball K; Immunology and Inflammation Research Therapeutic Area at Sanofi, Cambridge, MA, USA.
  • Upton JW; Innate Immunity Research Unit, GlaxoSmithKline, Collegeville, PA, USA.
  • Meier P; Innate Immunity Research Unit, GlaxoSmithKline, Collegeville, PA, USA.
Nat Commun ; 12(1): 3364, 2021 06 07.
Article en En | MEDLINE | ID: mdl-34099649
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Quinasas / Piel / Infecciones por Herpesviridae / Lisina Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Quinasas / Piel / Infecciones por Herpesviridae / Lisina Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2021 Tipo del documento: Article