2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
Arthritis Care Res (Hoboken)
; 73(7): 924-939, 2021 07.
Article
en En
| MEDLINE
| ID: mdl-34101387
ABSTRACT
OBJECTIVE:
To develop updated guidelines for the pharmacologic management of rheumatoid arthritis.METHODS:
We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising clinicians and patients achieved consensus on the direction (for or against) and strength (strong or conditional) of recommendations.RESULTS:
The guideline addresses treatment with disease-modifying antirheumatic drugs (DMARDs), including conventional synthetic DMARDs, biologic DMARDs, and targeted synthetic DMARDs, use of glucocorticoids, and use of DMARDs in certain high-risk populations (i.e., those with liver disease, heart failure, lymphoproliferative disorders, previous serious infections, and nontuberculous mycobacterial lung disease). The guideline includes 44 recommendations (7 strong and 37 conditional).CONCLUSION:
This clinical practice guideline is intended to serve as a tool to support clinician and patient decision-making. Recommendations are not prescriptive, and individual treatment decisions should be made through a shared decision-making process based on patients' values, goals, preferences, and comorbidities.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Reumatología
/
Antirreumáticos
Tipo de estudio:
Diagnostic_studies
/
Guideline
/
Prognostic_studies
/
Systematic_reviews
Idioma:
En
Revista:
Arthritis Care Res (Hoboken)
Asunto de la revista:
REUMATOLOGIA
Año:
2021
Tipo del documento:
Article