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Optimization of the clofazimine structure leads to a highly water-soluble C3-aminopyridinyl riminophenazine endowed with improved anti-Wnt and anti-cancer activity in vitro and in vivo.
Koval, Alexey; Bassanini, Ivan; Xu, Jiabin; Tonelli, Michele; Boido, Vito; Sparatore, Fabio; Amant, Frederic; Annibali, Daniela; Leucci, Eleonora; Sparatore, Anna; Katanaev, Vladimir L.
Afiliación
  • Koval A; Department of Cell Physiology and Metabolism, Translational Research Centre in Oncohaematology, Faculty of Medicine, University of Geneva, 1206, Geneva, Switzerland.
  • Bassanini I; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, 20133, Milano, Italy; Istituto di Scienze e Tecnologie Chimiche "Giulio Natta", Consiglio Nazonale delle Ricerche, 20131, Milano, Italy.
  • Xu J; Department of Cell Physiology and Metabolism, Translational Research Centre in Oncohaematology, Faculty of Medicine, University of Geneva, 1206, Geneva, Switzerland; Department of Biomedical Sciences, Faculty of Biology and Medicine, 1011, University of Lausanne, Lausanne, Switzerland.
  • Tonelli M; Dipartimento di Farmacia, Università di Genova, 16132, Genova, Italy.
  • Boido V; Dipartimento di Farmacia, Università di Genova, 16132, Genova, Italy.
  • Sparatore F; Dipartimento di Farmacia, Università di Genova, 16132, Genova, Italy.
  • Amant F; Gynecological Oncology Laboratory, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals Leuven and Department of Oncology, 3000, Leuven, Belgium; Centre for Gynecologic Oncology Amsterdam (CGOA), Ant
  • Annibali D; Gynecological Oncology Laboratory, Department of Oncology, KU Leuven and Leuven Cancer Institute (LKI), 3000, Leuven, Belgium.
  • Leucci E; Laboratory for RNA Cancer Biology, Department of Oncology, KU Leuven, 3000, Leuven, Belgium; Trace, LKI Leuven Cancer Institute, KU Leuven, 3000, Leuven, Belgium.
  • Sparatore A; Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, 20133, Milano, Italy. Electronic address: anna.sparatore@unimi.it.
  • Katanaev VL; Department of Cell Physiology and Metabolism, Translational Research Centre in Oncohaematology, Faculty of Medicine, University of Geneva, 1206, Geneva, Switzerland; School of Biomedicine, Far Eastern Federal University, 690922, Vladivostok, Russia. Electronic address: vladimir.katanaev@unige.ch.
Eur J Med Chem ; 222: 113562, 2021 Oct 15.
Article en En | MEDLINE | ID: mdl-34116325
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fenazinas / Clofazimina Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fenazinas / Clofazimina Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article