Comparative study of optical coherence tomography angiography algorithms for rodent retinal imaging.
Exp Biol Med (Maywood)
; 246(20): 2207-2213, 2021 10.
Article
en En
| MEDLINE
| ID: mdl-34120494
ABSTRACT
Optical coherence tomography angiography (OCTA) is a functional extension of optical coherence tomography for non-invasive in vivo three-dimensional imaging of the microvasculature of biological tissues. Several algorithms have been developed to construct OCTA images from the measured optical coherence tomography signals. In this study, we compared the performance of three OCTA algorithms that are based on the variance of phase, amplitude, and the complex representations of the optical coherence tomography signals for rodent retinal imaging, namely the phase variance, improved speckle contrast, and optical microangiography. The performance of the different algorithms was evaluated by comparing the quality of the OCTA images regarding how well the vasculature network can be resolved. Quantities that are widely used in ophthalmic studies including blood vessel density, vessel diameter index, vessel perimeter index, vessel complexity index were also compared. Results showed that both the improved speckle contrast and optical microangiography algorithms are more robust than phase variance, and they can reveal similar vasculature features while there are statistical differences in the calculated quantities.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Vasos Retinianos
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Tomografía de Coherencia Óptica
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Microvasos
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Angiografía por Tomografía Computarizada
Idioma:
En
Revista:
Exp Biol Med (Maywood)
Asunto de la revista:
BIOLOGIA
/
FISIOLOGIA
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MEDICINA
Año:
2021
Tipo del documento:
Article