Comprehensive Size Distribution and Composition Analysis of Adeno-Associated Virus Vector by Multiwavelength Sedimentation Velocity Analytical Ultracentrifugation.

Maruno, Takahiro; Usami, Kaede; Ishii, Kentaro; Torisu, Tetsuo; Uchiyama, Susumu

Maruno, Takahiro; Usami, Kaede; Ishii, Kentaro; Torisu, Tetsuo; Uchiyama, Susumu.

Afiliación

Maruno T; Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Usami K; Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Ishii K; Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Torisu T; Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Uchiyama S; Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan. Electronic address: suchi@bio.eng.osaka-u.ac.jp.

J Pharm Sci ; 110(10): 3375-3384, 2021 10.

Article en En | MEDLINE | ID: mdl-34186069

Asunto(s)

Dependovirus; Vectores Genéticos; Proteínas de la Cápside; Dependovirus/genética; Ultracentrifugación; Virión

Palabras clave

Adeno-associated virus (AAV); Analytical ultra-centrifugation; Biopharmaceutical characterization; Gene therapy; Physicochemical properties; Refractive index; UV/VIS spectroscopy; Viral vector(s)

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Dependovirus / Vectores Genéticos Tipo de estudio: Risk_factors_studies Idioma: En Revista: J Pharm Sci Año: 2021 Tipo del documento: Article

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