Anti-SARS-CoV-2 Repurposing Drug Database: Clinical Pharmacology Considerations.
CPT Pharmacometrics Syst Pharmacol
; 10(9): 973-982, 2021 09.
Article
en En
| MEDLINE
| ID: mdl-34218521
ABSTRACT
A critical step to evaluate the potential in vivo antiviral activity of a drug is to connect the in vivo exposure to its in vitro antiviral activity. The Anti-SARS-CoV-2 Repurposing Drug Database is a database that includes both in vitro anti-SARS-CoV-2 activity and in vivo pharmacokinetic data to facilitate the extrapolation from in vitro antiviral activity to potential in vivo antiviral activity for a large set of drugs/compounds. In addition to serving as a data source for in vitro anti-SARS-CoV-2 activity and in vivo pharmacokinetic information, the database is also a calculation tool that can be used to compare the in vitro antiviral activity with in vivo drug exposure to identify potential anti-SARS-CoV-2 drugs. Continuous development and expansion are feasible with the public availability of this database.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Bases de Datos Farmacéuticas
/
SARS-CoV-2
Idioma:
En
Revista:
CPT Pharmacometrics Syst Pharmacol
Año:
2021
Tipo del documento:
Article