Triptolide dose-dependently improves LPS-induced alveolar hypercoagulation and fibrinolysis inhibition through NF-&#954;B inactivation in ARDS mice.

Yang, Huilin; Qian, Hong; Liu, Bo; Wu, Yanqi; Cheng, Yumei; Zheng, Xinghao; Li, Xiang; Yang, Guixia; He, Tianhui; Li, Shuwen; Shen, Feng

Triptolide dose-dependently improves LPS-induced alveolar hypercoagulation and fibrinolysis inhibition through NF-κB inactivation in ARDS mice.

Yang, Huilin; Qian, Hong; Liu, Bo; Wu, Yanqi; Cheng, Yumei; Zheng, Xinghao; Li, Xiang; Yang, Guixia; He, Tianhui; Li, Shuwen; Shen, Feng.

Afiliación

Yang H; Department of Intensive Care Unit, Guizhou Medical University Affiliated Hospital, Guiyang 550001, China. Electronic address: 1402491244@qq.com.
Qian H; Department of Intensive Care Unit, Guizhou Medical University Affiliated Hospital, Guiyang 550001, China. Electronic address: 442495402@qq.com.
Liu B; Department of Intensive Care Unit, Guizhou Medical University Affiliated Hospital, Guiyang 550001, China. Electronic address: woniu891003@126.com.
Wu Y; Department of Intensive Care Unit, Guizhou Medical University Affiliated Hospital, Guiyang 550001, China. Electronic address: 398963843@qq.com.
Cheng Y; Department of Intensive Care Unit, Guizhou Medical University Affiliated Hospital, Guiyang 550001, China. Electronic address: 64960877@qq.com.
Zheng X; Department of Intensive Care Unit, Guizhou Medical University Affiliated Hospital, Guiyang 550001, China. Electronic address: 878653663@qq.com.
Li X; Department of Intensive Care Unit, Guizhou Medical University Affiliated Hospital, Guiyang 550001, China. Electronic address: 349866521@qq.com.
Yang G; Department of Intensive Care Unit, Guizhou Medical University Affiliated Hospital, Guiyang 550001, China. Electronic address: 2321648372@qq.com.
He T; Department of Intensive Care Unit, Guizhou Medical University Affiliated Hospital, Guiyang 550001, China. Electronic address: 382574528@qq.com.
Li S; Department of Intensive Care Unit, Guizhou Medical University Affiliated Hospital, Guiyang 550001, China. Electronic address: 1426766164@qq.com.
Shen F; Department of Intensive Care Unit, Guizhou Medical University Affiliated Hospital, Guiyang 550001, China. Electronic address: doctorshenfeng@163.com.

Biomed Pharmacother ; 139: 111569, 2021 Jul.

Article en En | MEDLINE | ID: mdl-34243622

Asunto(s)

Diterpenos/farmacología; Fibrinólisis/efectos de los fármacos; Lipopolisacáridos/farmacología; Pulmón/efectos de los fármacos; FN-kappa B/metabolismo; Fenantrenos/farmacología; Trombofilia/inducido químicamente; Trombofilia/tratamiento farmacológico; Animales; Modelos Animales de Enfermedad; Compuestos Epoxi/farmacología; Pulmón/metabolismo; Lesión Pulmonar/tratamiento farmacológico; Lesión Pulmonar/metabolismo; Masculino; Ratones; Ratones Endogámicos C57BL; Síndrome de Dificultad Respiratoria; Transducción de Señal/efectos de los fármacos; Trombofilia/metabolismo; Tromboplastina/metabolismo

Palabras clave

NF-κB pathway; Triptolide; acute respiratory distress syndrome; alveolar hypercoagulation and fibrinolysis inhibition

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fenantrenos / Lipopolisacáridos / FN-kappa B / Trombofilia / Diterpenos / Fibrinólisis / Pulmón Tipo de estudio: Prognostic_studies Idioma: En Revista: Biomed Pharmacother Año: 2021 Tipo del documento: Article

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