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Early phago-/endosomal escape of platinum drugs via ROS-responsive micelles for dual cancer chemo/immunotherapy.
Shueng, Pei-Wei; Yu, Lu-Yi; Chiu, Hsin-Cheng; Chang, Hui-Ching; Chiu, Yen-Ling; Kuo, Tzu-Yu; Yen, Yu-Wei; Lo, Chun-Liang.
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  • Shueng PW; Division of Radiation Oncology, Far Eastern Memorial Hospital, New Taipei City, 220, Taiwan, ROC; Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan, ROC; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, 112, Taiwan,
  • Yu LY; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan, ROC; Department of Biomedical Engineering, National Yang-Ming University, Taipei, 112, Taiwan, ROC.
  • Chiu HC; Department of Biomedical Engineering and Environmental Sciences, National Tsing-Hua University, Hsinchu, 300, Taiwan, ROC.
  • Chang HC; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan, ROC; Department of Biomedical Engineering, National Yang-Ming University, Taipei, 112, Taiwan, ROC.
  • Chiu YL; Graduate Program in Biomedical Informatics and Graduate Institute of Medicine, Yuan Ze University, Taoyuan City, 320, Taiwan, ROC; Graduate Institute of Clinical Medicine, National Taiwan University, Taipei, 100, Taiwan, ROC; Department of Medical Research, Far Eastern Memorial Hospital, New Taipei
  • Kuo TY; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan, ROC; Department of Biomedical Engineering, National Yang-Ming University, Taipei, 112, Taiwan, ROC.
  • Yen YW; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan, ROC; Department of Biomedical Engineering, National Yang-Ming University, Taipei, 112, Taiwan, ROC.
  • Lo CL; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan, ROC; Department of Biomedical Engineering, National Yang-Ming University, Taipei, 112, Taiwan, ROC; Center for Advanced Pharmaceutics and Drug Delivery Research, National Yang Ming Chiao Tung Univers
Biomaterials ; 276: 121012, 2021 09.
Article en En | MEDLINE | ID: mdl-34252800
ABSTRACT
Recent studies have indicated that cancer treatment based on immunotherapy alone is not viable. Combined treatment with other strategies is required to achieve the expected therapeutic effect. Reactive oxygen species (ROS) play an important role in regulating cancer cells and the tumor microenvironment, even in immune cells. However, rigorous regulation of the ROS level within the entire tumor tissue is difficult, limiting the application of ROS in cancer therapy. Therefore, we design an early phago-/endosome-escaping micelle that can release platinum-based drugs into the cytoplasm of macrophages and cancer cells, thereby enhancing the ROS levels of the entire tumor tissue; inducing apoptosis of cancer cells, down-regulation of CD47 expression of cancer cells, polarization of M1 macrophages, and phagocytosis of cancer cells by M1 macrophages; and achieving the dual effect of chemotherapy and macrophage-mediated immunotherapy.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Micelas / Neoplasias Idioma: En Revista: Biomaterials Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Micelas / Neoplasias Idioma: En Revista: Biomaterials Año: 2021 Tipo del documento: Article