Amended Safety Assessment of Methylchloroisothiazolinone and Methylisothiazolinone as Used in Cosmetics.
Int J Toxicol
; 40(1_suppl): 20S-33S, 2021.
Article
en En
| MEDLINE
| ID: mdl-34259066
ABSTRACT
The Expert Panel for Cosmetic Ingredient Safety (Panel) reassessed the safety of the mixture Methylchloroisothiazolinone (MCI)/Methylisothiazolinone (MI), which functions as a preservative in cosmetic products. The Panel reviewed relevant animal and human data provided in this safety assessment, and data from the previously published safety assessment of this mixture, and concluded that MCI/MI is safe in cosmetics when formulated to be nonsensitizing, based on the results of a quantitative risk assessment or similar methodology; however, at no point should concentrations exceed 7.5 ppm in leave-on products or 15 ppm in rinse-off products.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Conservadores Farmacéuticos
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Tiazoles
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Cosméticos
/
Haptenos
Tipo de estudio:
Etiology_studies
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Risk_factors_studies
Idioma:
En
Revista:
Int J Toxicol
Asunto de la revista:
TOXICOLOGIA
Año:
2021
Tipo del documento:
Article