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Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies.
Armstrong, Lee A; Lange, Sven M; Dee Cesare, Virginia; Matthews, Stephen P; Nirujogi, Raja Sekhar; Cole, Isobel; Hope, Anthony; Cunningham, Fraser; Toth, Rachel; Mukherjee, Rukmini; Bojkova, Denisa; Gruber, Franz; Gray, David; Wyatt, Paul G; Cinatl, Jindrich; Dikic, Ivan; Davies, Paul; Kulathu, Yogesh.
Afiliación
  • Armstrong LA; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
  • Lange SM; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
  • Dee Cesare V; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
  • Matthews SP; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
  • Nirujogi RS; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
  • Cole I; MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
  • Hope A; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
  • Cunningham F; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
  • Toth R; MRC Reagents and Services, University of Dundee, Dundee, Scotland, United Kingdom.
  • Mukherjee R; Institute of Biochemistry II, Goethe University Frankfurt Medical Faculty, University Hospital, Frankfurt am Main, Germany.
  • Bojkova D; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany.
  • Gruber F; Institute of Medical Virology, University Hospital Frankfurt, Frankfurt am Main, Germany.
  • Gray D; National Phenotypic Screening Centre, University of Dundee, Dundee, Scotland, United Kingdom.
  • Wyatt PG; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
  • Cinatl J; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.
  • Dikic I; Institute of Medical Virology, University Hospital Frankfurt, Frankfurt am Main, Germany.
  • Davies P; Institute of Biochemistry II, Goethe University Frankfurt Medical Faculty, University Hospital, Frankfurt am Main, Germany.
  • Kulathu Y; Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany.
PLoS One ; 16(7): e0253364, 2021.
Article en En | MEDLINE | ID: mdl-34270554
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antivirales / Inhibidores de Proteasas / ARN Polimerasa Dependiente del ARN / Proteínas no Estructurales Virales / Anticuerpos de Cadena Única Tipo de estudio: Prognostic_studies Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Antivirales / Inhibidores de Proteasas / ARN Polimerasa Dependiente del ARN / Proteínas no Estructurales Virales / Anticuerpos de Cadena Única Tipo de estudio: Prognostic_studies Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2021 Tipo del documento: Article