Endogenous formation of 1-propanol and methanol after consumption of alcoholic beverages.
Forensic Sci Int
; 325: 110905, 2021 Aug.
Article
en En
| MEDLINE
| ID: mdl-34280599
ABSTRACT
INTRODUCTION:
In cases of drunk-driving, allegations that alcohol has been consumed after the incident, are proved by analyzing congener alcohols in the blood sample. 1-Propanol, one of the main congener compounds, was tested, whether it is also endogenously formed when a person has consumed alcoholic beverages.METHODS:
Eleven male and 13 female volunteers consumed congener-free vodka (37.5 vol% ethanol, individual doses 0.15-0.32 l) within one hour. Blood samples were taken up to 10 h and analyzed for ethanol and congener alcohols by headspace gas chromatography-mass spectrometry.RESULTS:
Ethanol concentrations reached in blood a maximum of 0.65-1.23 g/l and decreased by 0.18 g/l/h (median values). Of the congener alcohols analyzed, only methanol and 1-propanol were detected in the plasma samples of all subjects. The endogenous methanol concentration increased from 0.66 mg/l by 0.22 mg/l/h to 2.19 mg/l (medians). 1-Propanol was not detected prior to alcohol consumption. Maximum concentrations of 0.10-0.32 mg/L were measured after 1.0-4.5 h. A plateau of the 1-propanol concentration was observed in the plasma samples of the 18 subjects lasting for 0.5-4.0 h and this alcohol was completely eliminated at ethanol concentrations of 0.17 g/l (median, range 0.03-0.55 g/l).CONCLUSION:
The results of the study confirm the formation of 1-propanol after consumption of 1-propanol-free beverages, which should be taken into account when evaluating its concentration.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Consumo de Bebidas Alcohólicas
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Depresores del Sistema Nervioso Central
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Etanol
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Metanol
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1-Propanol
Idioma:
En
Revista:
Forensic Sci Int
Año:
2021
Tipo del documento:
Article