Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology.

Xu, Ranjie; Boreland, Andrew J; Li, Xiaoxi; Erickson, Caroline; Jin, Mengmeng; Atkins, Colm; Pang, Zhiping P; Daniels, Brian P; Jiang, Peng

Xu, Ranjie; Boreland, Andrew J; Li, Xiaoxi; Erickson, Caroline; Jin, Mengmeng; Atkins, Colm; Pang, Zhiping P; Daniels, Brian P; Jiang, Peng.

Afiliación

Xu R; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: ranjie.xu@rutgers.edu.
Boreland AJ; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA; Graduate Program in Molecular Biosciences, Rutgers University, Piscataway, NJ 08854, USA.
Li X; Department of Immunology, Nanjing Medical University, Nanjing, China.
Erickson C; Summer Undergraduate Research Program in Neuroscience (NeuroSURP), Rutgers Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
Jin M; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Atkins C; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Pang ZP; Department of Neuroscience and Cell Biology and Child Health Institute of New Jersey, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
Daniels BP; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA.
Jiang P; Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: peng.jiang@rutgers.edu.

Stem Cell Reports ; 16(8): 1923-1937, 2021 08 10.

Article en En | MEDLINE | ID: mdl-34297942

Asunto(s)

Encéfalo/metabolismo; Microglía/metabolismo; Organoides/metabolismo; Células Madre Pluripotentes/metabolismo; Encéfalo/citología; Diferenciación Celular/genética; Línea Celular; Células Cultivadas; Técnicas de Cocultivo; Perfilación de la Expresión Génica/métodos; Humanos; Células Madre Pluripotentes Inducidas/metabolismo; Microglía/citología; Microglía/virología; Modelos Neurológicos; Células-Madre Neurales/metabolismo; Organoides/citología; Organoides/virología; Sinapsis/genética; Virus Zika/fisiología; Infección por el Virus Zika/metabolismo; Infección por el Virus Zika/virología

Palabras clave

Zika virus; cerebral organoid; human iPSC; human pluripotent stem cell; microglia; synaptic pruning

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Encéfalo / Organoides / Microglía / Células Madre Pluripotentes Tipo de estudio: Prognostic_studies Idioma: En Revista: Stem Cell Reports Año: 2021 Tipo del documento: Article

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