A case of inflammatory myopathy in graft vs host disease - A potential role for ibrutinib.
Neuromuscul Disord
; 31(9): 865-869, 2021 09.
Article
en En
| MEDLINE
| ID: mdl-34334272
ABSTRACT
Myositis is a known complication of chronic graft-vs-host disease (cGVHD) following allogeneic haematopoietic stem cell transplantation, but can be difficult to diagnose and manage. We present the case of a 57 year old man with cGVHD in whom the full manifestations of myositis were suppressed for some time, likely due to partial treatment of his condition with immunosuppression including ibrutinib. Though initial muscle biopsy showed necrotising myopathy without significant inflammation, on cessation of ibrutinib he developed increasing weakness and creatine kinase levels, with repeat muscle biopsy showing histological changes more in keeping with dermatomyositis. The close temporal correlation of his clinical course with commencement and cessation of ibrutinib suggests a potential role for ibrutinib in treating inflammatory myopathy in cGVHD.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Piperidinas
/
Adenina
/
Enfermedad Injerto contra Huésped
/
Inmunosupresores
/
Miositis
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Neuromuscul Disord
Asunto de la revista:
NEUROLOGIA
Año:
2021
Tipo del documento:
Article