Privileged scaffolds in medicinal chemistry: Studies on pyrazolo[1,5-a]pyrimidines on sulfonamide containing Carbonic Anhydrase inhibitors.

Gumus, Arzu; Bozdag, Murat; Angeli, Andrea; Peat, Thomas S; Carta, Fabrizio; Supuran, Claudiu T; Selleri, Silvia

Gumus, Arzu; Bozdag, Murat; Angeli, Andrea; Peat, Thomas S; Carta, Fabrizio; Supuran, Claudiu T; Selleri, Silvia.

Afiliación

Gumus A; Balikesir University, Faculty of Science and Art, Department of Chemistry, 10145 Balikesir, Turkey.
Bozdag M; NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino (FI), Italy.
Angeli A; NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino (FI), Italy.
Peat TS; CSIRO, 343 Royal Parade, Parkville, Victoria 3052, Australia.
Carta F; NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino (FI), Italy. Electronic address: fabrizio.carta@unifi.it.
Supuran CT; NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino (FI), Italy.
Selleri S; NEUROFARBA Department, Pharmaceutical and Nutraceutical Section, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino (FI), Italy. Electronic address: silvia.selleri@unifi.it.

Bioorg Med Chem Lett ; 49: 128309, 2021 10 01.

Article en En | MEDLINE | ID: mdl-34371130

Asunto(s)

Inhibidores de Anhidrasa Carbónica/química; Pirazoles/química; Pirimidinas/química; Sulfonamidas/química; Inhibidores de Anhidrasa Carbónica/síntesis química; Inhibidores de Anhidrasa Carbónica/metabolismo; Anhidrasas Carbónicas/química; Anhidrasas Carbónicas/metabolismo; Dominio Catalítico; Cristalografía por Rayos X; Humanos; Estructura Molecular; Unión Proteica; Pirazoles/síntesis química; Pirazoles/metabolismo; Pirimidinas/síntesis química; Pirimidinas/metabolismo; Relación Estructura-Actividad; Sulfonamidas/síntesis química; Sulfonamidas/metabolismo

Palabras clave

Carbonic Anhydrase inhibitors; Privilege scaffolds; Pyrazolopyrimidines; X-ray crystallography

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Sulfonamidas / Inhibidores de Anhidrasa Carbónica Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article

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