Within-visit SBP variability from childhood to adulthood and markers of cardiovascular end-organ damage in mid-life.
J Hypertens
; 39(9): 1865-1875, 2021 09 01.
Article
en En
| MEDLINE
| ID: mdl-34397629
ABSTRACT
BACKGROUND:
Within-visit SBP variability is associated with age and SBP, but its long-term clinical significance is unknown. We examined the association between child, adult, and life-time within-visit SBP variability with markers of end-organ damage using data from a 31-year longitudinal study.METHODS:
Within-visit SBP variability was calculated as the standard deviation of three sitting SBP readings among up to 3010 participants aged 6-18âyears (childhood) who were re-measured up to seven times to mid-adulthood. Markers of cardiovascular end-organ damage in adulthood were carotid intima--media thickness, brachial flow-mediated dilatation, carotid distensibility, pulse wave velocity, left ventricular mass index, carotid plaque, and coronary artery calcification.RESULTS:
The mean (standard deviation) cumulative within-visit SBP variability was 2.7 (1.5) mmHg in childhood, 3.9 (1.9) mmHg in adulthood and 3.7 (1.5) mmHg across the observed life-time. Childhood within-visit SBP variability was not correlated with its subsequent values measured from 3 to 31 years later. With adjustment for age, sex, cumulative SBP, BMI and serum lipids, neither child, adult, or life-time cumulative within-visit SBP variability associated with markers of cardiovascular end-organ damage. However, higher child, adult, and life-time cumulative SBP significantly associated with higher carotid intima--media thickness, higher pulse wave velocity, lower brachial flow-mediated dilatation, lower carotid distensibility in adulthood.CONCLUSION:
Within-visit SBP variability from childhood to adulthood does not provide additional predictive utility over SBP over the same period of the life course.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Grosor Intima-Media Carotídeo
/
Análisis de la Onda del Pulso
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
J Hypertens
Año:
2021
Tipo del documento:
Article