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Novel C-3-(N-alkyl-aryl)-aminomethyl rifamycin SV derivatives exhibit activity against rifampicin-resistant Mycobacterium tuberculosis RpoBS522L strain and display a different binding mode at the RNAP ß-subunit site compared to rifampicin.
Zloh, Mire; Gupta, Megha; Parish, Tanya; Brucoli, Federico.
Afiliación
  • Zloh M; Faculty of Pharmacy, University Business Academy, Novi Sad, 2100, Serbia; UCL School of Pharmacy, UCL, London, WC1N 1AX, UK.
  • Gupta M; Infectious Disease Research Institute, 1616 Eastlake Ave E, Suite 400, Seattle, WA, 98102, USA.
  • Parish T; Center for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, USA.
  • Brucoli F; Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK. Electronic address: federico.brucoli@dmu.ac.uk.
Eur J Med Chem ; 225: 113734, 2021 Dec 05.
Article en En | MEDLINE | ID: mdl-34418786
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Rifamicinas / Tuberculosis Resistente a Múltiples Medicamentos / Mycobacterium tuberculosis / Antituberculosos Tipo de estudio: Prognostic_studies Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Rifamicinas / Tuberculosis Resistente a Múltiples Medicamentos / Mycobacterium tuberculosis / Antituberculosos Tipo de estudio: Prognostic_studies Idioma: En Revista: Eur J Med Chem Año: 2021 Tipo del documento: Article