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Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors.
Chafe, Shawn C; Vizeacoumar, Frederick S; Venkateswaran, Geetha; Nemirovsky, Oksana; Awrey, Shannon; Brown, Wells S; McDonald, Paul C; Carta, Fabrizio; Metcalfe, Andrew; Karasinska, Joanna M; Huang, Ling; Muthuswamy, Senthil K; Schaeffer, David F; Renouf, Daniel J; Supuran, Claudiu T; Vizeacoumar, Franco J; Dedhar, Shoukat.
Afiliación
  • Chafe SC; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
  • Vizeacoumar FS; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 0W8, Canada.
  • Venkateswaran G; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
  • Nemirovsky O; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
  • Awrey S; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
  • Brown WS; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
  • McDonald PC; Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, BC V5Z 1L3, Canada.
  • Carta F; NEUROFARBA Department, University of Florence, Via U. Schiff 6, Florence 50019, Italy.
  • Metcalfe A; Pancreas Centre BC, Vancouver, BC V3Z 1M9, Canada.
  • Karasinska JM; Pancreas Centre BC, Vancouver, BC V3Z 1M9, Canada.
  • Huang L; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Muthuswamy SK; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Schaeffer DF; Pancreas Centre BC, Vancouver, BC V3Z 1M9, Canada.
  • Renouf DJ; Department of Pathology and Laboratory Medicine, Vancouver General Hospital, Vancouver, BC V5Z 1M9, Canada.
  • Supuran CT; Pancreas Centre BC, Vancouver, BC V3Z 1M9, Canada.
  • Vizeacoumar FJ; Medical Oncology, BC Cancer, Vancouver, BC V5Z 4E67, Canada.
  • Dedhar S; NEUROFARBA Department, University of Florence, Via U. Schiff 6, Florence 50019, Italy.
Sci Adv ; 7(35)2021 08.
Article en En | MEDLINE | ID: mdl-34452919
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Bicarbonatos / Neoplasias Tipo de estudio: Prognostic_studies Idioma: En Revista: Sci Adv Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Bicarbonatos / Neoplasias Tipo de estudio: Prognostic_studies Idioma: En Revista: Sci Adv Año: 2021 Tipo del documento: Article