Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium.

Ahmed, Tofayel; Nisler, Collin R; Fluck, Edwin C; Walujkar, Sanket; Sotomayor, Marcos; Moiseenkova-Bell, Vera Y

Ahmed, Tofayel; Nisler, Collin R; Fluck, Edwin C; Walujkar, Sanket; Sotomayor, Marcos; Moiseenkova-Bell, Vera Y.

Afiliación

Ahmed T; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nisler CR; Biophysics Graduate Program, The Ohio State University, Columbus, OH 43210, USA; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
Fluck EC; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Walujkar S; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; Chemical Physics Graduate Program, The Ohio State University, Columbus, OH 43210, USA.
Sotomayor M; Biophysics Graduate Program, The Ohio State University, Columbus, OH 43210, USA; Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA; Chemical Physics Graduate Program, The Ohio State University, Columbus, OH 43210, USA.
Moiseenkova-Bell VY; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: vmb@pennmedicine.upenn.edu.

Structure ; 30(1): 139-155.e5, 2022 01 06.

Article en En | MEDLINE | ID: mdl-34453887

Asunto(s)

Calcio/metabolismo; Fosfatos de Fosfatidilinositol/farmacología; Proteínas de Saccharomyces cerevisiae/química; Proteínas de Saccharomyces cerevisiae/metabolismo; Saccharomyces cerevisiae/metabolismo; Canales Catiónicos TRPC/química; Canales Catiónicos TRPC/metabolismo; Sitios de Unión; Microscopía por Crioelectrón; Citosol/metabolismo; Modelos Moleculares; Simulación de Dinámica Molecular; Fosfatos de Fosfatidilinositol/química; Conformación Proteica; Dominios Proteicos; Multimerización de Proteína; Saccharomyces cerevisiae/química

Palabras clave

calcium; cryo electron microscopy (cryo-EM); ion channel; membrane protein; molecular dynamics simulation; transient receptor potential (TRP) channel

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Saccharomyces cerevisiae / Calcio / Fosfatos de Fosfatidilinositol / Proteínas de Saccharomyces cerevisiae / Canales Catiónicos TRPC Tipo de estudio: Prognostic_studies Idioma: En Revista: Structure Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Año: 2022 Tipo del documento: Article

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