ABSTRACT
It is a common but flawed presumption that blood lactate reflects the lactic acid production in the body's tissues. Lactate is formed directly from pyruvate and functions to dampen reductions in intracellular pH through lactate-H+ cotransport to the extracellular space. Though this may give rise to elevated blood lactate, increased lactate production is not the cause of metabolic acidosis in such instances. "Lactic acidosis" is thus an inappropriate term as it indicates causality and in this review, we suggest that in the future, the term "hyperlactataemia-associated metabolic acidosis" should be used instead.
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Base de datos:
MEDLINE
Asunto principal:
Acidosis
/
Acidosis Láctica
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Idioma:
Da
Revista:
Ugeskr Laeger
Año:
2021
Tipo del documento:
Article