Alterations of Ocular Surface Parameters in Type 2 Diabetic Patients.
Diabetes Metab Syndr Obes
; 14: 3787-3793, 2021.
Article
en En
| MEDLINE
| ID: mdl-34483673
ABSTRACT
OBJECTIVE:
The purpose of the study was to evaluate the changes in the ocular surface parameters of type 2 diabetic patients.METHODS:
This study is a cross-sectional observational study. It included 76 eyes of 38 patients with type 2 diabetes and 183 eyes of 92 non-diabetic controls. The diabetic subjects were divided into two groups based on diabetic duration. Ocular surface parameters were assessed for all participants.RESULTS:
The diabetic group had a significantly thinner lipid layer thickness (LLT) (p = 0.008) than non-diabetic controls. LLT in the subgroup with diabetic duration ≥10 years was significantly thinner than that in the subgroup with diabetic duration <10 years (p = 0.006). Multivariate linear regression analysis showed that LLT was associated with the duration of diabetes (ß = -1.497, p = 0.009) and Schirmer I test (SIT) score (ß = 0.852, p = 0.04) in diabetic. Diabetic duration was significantly negatively associated with LLT (ß = -0.062, p = 0.004) and significantly positively associated with ocular surface disease index (OSDI) (ß = 0.087, p = 0.039).CONCLUSION:
Diabetic patients exhibit significantly reduced LLT and this trend becomes more pronounced with increased duration of diabetes.
Texto completo:
1
Base de datos:
MEDLINE
Tipo de estudio:
Observational_studies
Idioma:
En
Revista:
Diabetes Metab Syndr Obes
Año:
2021
Tipo del documento:
Article