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Stereochemical characterisation of the non-canonical α-humulene synthase from Acremonium strictum.
Xu, Houchao; Schotte, Carsten; Cox, Russell J; Dickschat, Jeroen S.
Afiliación
  • Xu H; Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, 53121 Bonn, Germany. dickschat@uni-bonn.de.
  • Schotte C; Institute of Organic Chemistry, University of Hannover, Schneiderberg 38, 30167 Hannover, Germany.
  • Cox RJ; Institute of Organic Chemistry, University of Hannover, Schneiderberg 38, 30167 Hannover, Germany.
  • Dickschat JS; Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, 53121 Bonn, Germany. dickschat@uni-bonn.de.
Org Biomol Chem ; 19(39): 8482-8486, 2021 10 14.
Article en En | MEDLINE | ID: mdl-34533184
ABSTRACT
The non-canonical fungal α-humulene synthase was investigated through isotopic labelling experiments for its stereochemical course regarding inversion or retention at C-1, the face selectivity at C-11, and the stereoselectivity of the final deprotonation. A new and convenient desymmetrisation strategy was developed to enable a full stereochemical analysis of the catalysed steps to the achiral α-humulene product from stereoselectively labelled farnesyl diphosphate.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Hypocreales Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Hypocreales Idioma: En Revista: Org Biomol Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article