Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure.

Campagno, Keith E; Lu, Wennan; Jassim, Assraa Hassan; Albalawi, Farraj; Cenaj, Aurora; Tso, Huen-Yee; Clark, Sophia P; Sripinun, Puttipong; Gómez, Néstor Más; Mitchell, Claire H

Campagno, Keith E; Lu, Wennan; Jassim, Assraa Hassan; Albalawi, Farraj; Cenaj, Aurora; Tso, Huen-Yee; Clark, Sophia P; Sripinun, Puttipong; Gómez, Néstor Más; Mitchell, Claire H.

Afiliación

Campagno KE; Department of Basic and Translational Science, University of Pennsylvania, 240 S. 40th St, Philadelphia, PA, 19104, USA.
Lu W; Department of Basic and Translational Science, University of Pennsylvania, 240 S. 40th St, Philadelphia, PA, 19104, USA.
Jassim AH; Department of Basic and Translational Science, University of Pennsylvania, 240 S. 40th St, Philadelphia, PA, 19104, USA.
Albalawi F; Department of Orthodontics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Cenaj A; Department of Preventive Dental Sciences, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Tso HY; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Clark SP; Department of Basic and Translational Science, University of Pennsylvania, 240 S. 40th St, Philadelphia, PA, 19104, USA.
Sripinun P; Department of Basic and Translational Science, University of Pennsylvania, 240 S. 40th St, Philadelphia, PA, 19104, USA.
Gómez NM; Department of Basic and Translational Science, University of Pennsylvania, 240 S. 40th St, Philadelphia, PA, 19104, USA.
Mitchell CH; Department of Orthodontics, University of Pennsylvania, Philadelphia, PA, 19104, USA.

J Neuroinflammation ; 18(1): 217, 2021 Sep 20.

Article en En | MEDLINE | ID: mdl-34544431

Asunto(s)

Glaucoma/metabolismo; Glaucoma/patología; Microglía/metabolismo; Microglía/patología; Receptores Purinérgicos P2X7/metabolismo; Animales; Ratones; Ratones Endogámicos C57BL; Regulación hacia Arriba

Palabras clave

ATP release; Chemoattraction migration; Glaucoma; Iba1; Intraocular pressure; Microglial M1/M2 activation; Neuroinflammation; P2X7 receptor; P2Y12 receptor; Sholl analysis; Traumatic brain injury

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Glaucoma / Microglía / Receptores Purinérgicos P2X7 Idioma: En Revista: J Neuroinflammation Asunto de la revista: NEUROLOGIA Año: 2021 Tipo del documento: Article

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