Quantifying T Cell Cross-Reactivity: Influenza and Coronaviruses.
Viruses
; 13(9)2021 09 07.
Article
en En
| MEDLINE
| ID: mdl-34578367
ABSTRACT
If viral strains are sufficiently similar in their immunodominant epitopes, then populations of cross-reactive T cells may be boosted by exposure to one strain and provide protection against infection by another at a later date. This type of pre-existing immunity may be important in the adaptive immune response to influenza and to coronaviruses. Patterns of recognition of epitopes by T cell clonotypes (a set of cells sharing the same T cell receptor) are represented as edges on a bipartite network. We describe different methods of constructing bipartite networks that exhibit cross-reactivity, and the dynamics of the T cell repertoire in conditions of homeostasis, infection and re-infection. Cross-reactivity may arise simply by chance, or because immunodominant epitopes of different strains are structurally similar. We introduce a circular space of epitopes, so that T cell cross-reactivity is a quantitative measure of the overlap between clonotypes that recognize similar (that is, close in epitope space) epitopes.
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MEDLINE
Asunto principal:
Virus de la Influenza A
/
Epítopos Inmunodominantes
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Infecciones por Coronavirus
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Coronavirus
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Reacciones Cruzadas
Idioma:
En
Revista:
Viruses
Año:
2021
Tipo del documento:
Article