Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-&#954;B Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo.

Cykowiak, Marta; Krajka-Kuzniak, Violetta; Kleszcz, Robert; Kucinska, Malgorzata; Szaefer, Hanna; Piotrowska-Kempisty, Hanna; Plewinski, Adam; Murias, Marek; Baer-Dubowska, Wanda

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo.

Cykowiak, Marta; Krajka-Kuzniak, Violetta; Kleszcz, Robert; Kucinska, Malgorzata; Szaefer, Hanna; Piotrowska-Kempisty, Hanna; Plewinski, Adam; Murias, Marek; Baer-Dubowska, Wanda.

Afiliación

Cykowiak M; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Swiecickiego Street, 60-781 Poznan, Poland.
Krajka-Kuzniak V; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Swiecickiego Street, 60-781 Poznan, Poland.
Kleszcz R; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Swiecickiego Street, 60-781 Poznan, Poland.
Kucinska M; Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznan, Poland.
Szaefer H; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Swiecickiego Street, 60-781 Poznan, Poland.
Piotrowska-Kempisty H; Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznan, Poland.
Plewinski A; Centre for Advanced Technologies, Adam Mickiewicz University, 10, Uniwersytetu Poznanskiego Street, 61-614 Poznan, Poland.
Murias M; Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznan, Poland.
Baer-Dubowska W; Department of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Swiecickiego Street, 60-781 Poznan, Poland.

Nutrients ; 13(9)2021 Aug 28.

Article en En | MEDLINE | ID: mdl-34578877

Asunto(s)

Anticarcinógenos/farmacología; Flavonoides/farmacología; Hepatoblastoma/metabolismo; Isotiocianatos/farmacología; Neoplasias Hepáticas/metabolismo; Factor 2 Relacionado con NF-E2/metabolismo; FN-kappa B/metabolismo; Propiofenonas/farmacología; Animales; Anticarcinógenos/uso terapéutico; Apoptosis; Inhibidores de la Ciclooxigenasa 2/farmacología; Inhibidores de la Ciclooxigenasa 2/uso terapéutico; Regulación hacia Abajo; Combinación de Medicamentos; Flavonoides/uso terapéutico; Células Hep G2; Hepatoblastoma/tratamiento farmacológico; Humanos; Isotiocianatos/uso terapéutico; Neoplasias Hepáticas/tratamiento farmacológico; Masculino; Ratones Endogámicos BALB C; Ratones Desnudos; NAD(P)H Deshidrogenasa (Quinona)/metabolismo; Propiofenonas/uso terapéutico; Transducción de Señal; Superóxido Dismutasa/metabolismo; Carga Tumoral; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

HepG2 and THLE-2 cells; NF-κB; Nrf2; mice xenograft model; phytochemicals combinations

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Propiofenonas / Flavonoides / FN-kappa B / Anticarcinógenos / Isotiocianatos / Hepatoblastoma / Factor 2 Relacionado con NF-E2 / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Idioma: En Revista: Nutrients Año: 2021 Tipo del documento: Article

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