Screening of a glycopolymer library for GM1 mimetics synthesized by the "carbohydrate module method".
Chem Commun (Camb)
; 57(83): 10871-10874, 2021 Oct 19.
Article
en En
| MEDLINE
| ID: mdl-34585193
ABSTRACT
The "carbohydrate module method" is a promising approach for oligosaccharide mimetics using polymeric materials. However, it is difficult to predict the optimal structure for a particular oligosaccharide mimetic, and an efficient strategy for the synthesis and evaluation of glycopolymers is desirable. In this study, a screening of glycopolymers for the "carbohydrate module method" by a combination of photoinduced electron/energy transfer-reversible addition-fragmentation chain-transfer (PET-RAFT) polymerization and surface plasmon resonance imaging (SPRI) is demonstrated. The facile and fast screening of synthetic glycomimetics was achieved, and the glycopolymer with the optimal structure as a GM1 mimetic strongly interacted with the cholera toxin B subunit.
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1
Base de datos:
MEDLINE
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2021
Tipo del documento:
Article