Symptomatic use of carbidopa in autonomic disorders.
Auton Neurosci
; 236: 102888, 2021 12.
Article
en En
| MEDLINE
| ID: mdl-34610497
ABSTRACT
Carbidopa is being explored as a novel therapy for hyperadrenergic symptoms of autonomic disorders, due to its potential to decrease peripheral catecholamine levels. This study retrospectively characterized patients in our autonomic clinic who were prescribed carbidopa for open label treatment of autonomic symptoms. 23 patients were included; approximately half had postural orthostatic tachycardia syndrome. Those with documented plasma catecholamines had elevated standing norepinephrine. Patients typically had multiple comorbidities and multiple failed therapies. 19 took carbidopa (typically 25 mg three times daily); 12 continued it for longer than 3 months. 11 patients reported better symptom control with carbidopa, most commonly tremor and gastrointestinal dysfunction. 4 patients reported side effects. In this small retrospective study, carbidopa was well tolerated in patients with dysautonomia, and half reported symptomatic benefit. Larger, placebo-controlled trials are warranted for further investigation of this therapy.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Carbidopa
/
Síndrome de Taquicardia Postural Ortostática
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
Idioma:
En
Revista:
Auton Neurosci
Asunto de la revista:
NEUROLOGIA
Año:
2021
Tipo del documento:
Article