Catecholamines in neuroblastoma: Driver of hypertension, or solely a marker of disease?
Cancer Rep (Hoboken)
; 5(8): e1569, 2022 08.
Article
en En
| MEDLINE
| ID: mdl-34612613
ABSTRACT
BACKGROUND:
Neuroblastoma is a common solid tumor of childhood and is often associated with hypertension. Potential etiologies contributing to hypertension include renal compression, pain, volume overload, and catecholamine secretion. CASES We completed a single center retrospective review of children with neuroblastoma and ≥stage II hypertension (per Hypertension Canada guidelines) over a 2-year period. All patients (n = 10) had elevated urine normetanephrine levels and eight had intra-abdominal tumors. Four patients had refractory hypertension requiring > three agents, of which three required alpha/beta blockade.CONCLUSION:
Although multifactorial, hypertension in neuroblastoma often has a neuroendocrine component. Excess normetanephrine production in neuroblastoma may be a more common hypertensive mechanism than previously appreciated. Urinary normetanephrine elevation could suggest potential neuroendocrine-mediated hypertension.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Hipertensión
/
Neuroblastoma
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
Idioma:
En
Revista:
Cancer Rep (Hoboken)
Año:
2022
Tipo del documento:
Article