Monocytes mediate Salmonella Typhimurium-induced tumor growth inhibition in a mouse melanoma model.
Eur J Immunol
; 51(12): 3228-3238, 2021 12.
Article
en En
| MEDLINE
| ID: mdl-34633664
The use of bacteria as an alternative cancer therapy has been reinvestigated in recent years. SL7207: an auxotrophic Salmonella enterica serovar Typhimurium aroA mutant with immune-stimulatory potential has proven a promising strain for this purpose. Here, we show that systemic administration of SL7207 induces melanoma tumor growth arrest in vivo, with greater survival of the SL7207-treated group compared to control PBS-treated mice. Administration of SL7207 is accompanied by a change in the immune phenotype of the tumor-infiltrating cells toward pro-inflammatory, with expression of the TH 1 cytokines IFN-γ, TNF-α, and IL-12 significantly increased. Interestingly, Ly6C+ MHCII+ monocytes were recruited to the tumors following SL7207 treatment and were pro-inflammatory. Accordingly, the abrogation of these infiltrating monocytes using clodronate liposomes prevented SL7207-induced tumor growth inhibition. These data demonstrate a previously unappreciated role for infiltrating inflammatory monocytes underlying bacterial-mediated tumor growth inhibition. This information highlights a possible novel role for monocytes in controlling tumor growth, contributing to our understanding of the immune responses required for successful immunotherapy of cancer.
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MEDLINE
Asunto principal:
Salmonella typhimurium
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Melanoma Experimental
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Monocitos
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Células TH1
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Inmunoterapia
Idioma:
En
Revista:
Eur J Immunol
Año:
2021
Tipo del documento:
Article