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USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.
Ruiz, E Josue; Pinto-Fernandez, Adan; Turnbull, Andrew P; Lan, Linxiang; Charlton, Thomas M; Scott, Hannah C; Damianou, Andreas; Vere, George; Riising, Eva M; Da Costa, Clive; Krajewski, Wojciech W; Guerin, David; Kearns, Jeffrey D; Ioannidis, Stephanos; Katz, Marie; McKinnon, Crystal; O'Connell, Jonathan; Moncaut, Natalia; Rosewell, Ian; Nye, Emma; Jones, Neil; Heride, Claire; Gersch, Malte; Wu, Min; Dinsmore, Christopher J; Hammonds, Tim R; Kim, Sunkyu; Komander, David; Urbe, Sylvie; Clague, Michael J; Kessler, Benedikt M; Behrens, Axel.
Afiliación
  • Ruiz EJ; Adult stem cell laboratory, The Francis Crick Institute, London, United Kingdom.
  • Pinto-Fernandez A; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Turnbull AP; London Bioscience Innovation Centre, CRUK Therapeutic Discovery Laboratories, London, United Kingdom.
  • Lan L; Adult stem cell laboratory, The Francis Crick Institute, London, United Kingdom.
  • Charlton TM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Scott HC; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Damianou A; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Vere G; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Riising EM; Adult stem cell laboratory, The Francis Crick Institute, London, United Kingdom.
  • Da Costa C; Adult stem cell laboratory, The Francis Crick Institute, London, United Kingdom.
  • Krajewski WW; London Bioscience Innovation Centre, CRUK Therapeutic Discovery Laboratories, London, United Kingdom.
  • Guerin D; FORMA Therapeutics, Watertown, United Kingdom.
  • Kearns JD; FORMA Therapeutics, Watertown, United Kingdom.
  • Ioannidis S; FORMA Therapeutics, Watertown, United Kingdom.
  • Katz M; FORMA Therapeutics, Watertown, United Kingdom.
  • McKinnon C; FORMA Therapeutics, Watertown, United Kingdom.
  • O'Connell J; FORMA Therapeutics, Watertown, United Kingdom.
  • Moncaut N; Genetic Manipulation Service, The Francis Crick Institute, London, United States.
  • Rosewell I; Genetic Manipulation Service, The Francis Crick Institute, London, United States.
  • Nye E; Adult stem cell laboratory, The Francis Crick Institute, London, United Kingdom.
  • Jones N; London Bioscience Innovation Centre, CRUK Therapeutic Discovery Laboratories, London, United Kingdom.
  • Heride C; London Bioscience Innovation Centre, CRUK Therapeutic Discovery Laboratories, London, United Kingdom.
  • Gersch M; Max Planck Institute of Molecular Physiology, Dortmund, Germany.
  • Wu M; FORMA Therapeutics, Watertown, United Kingdom.
  • Dinsmore CJ; FORMA Therapeutics, Watertown, United Kingdom.
  • Hammonds TR; London Bioscience Innovation Centre, CRUK Therapeutic Discovery Laboratories, London, United Kingdom.
  • Kim S; Incyte, Wilmington, United States.
  • Komander D; Ubiquitin Signalling Division, Walter and Eliza Hall Institute of Medical Research, Royal Parade, and Department of Medical Biology, University of Melbourne, Melbourne, Australia.
  • Urbe S; Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
  • Clague MJ; Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
  • Kessler BM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
  • Behrens A; Adult stem cell laboratory, The Francis Crick Institute, London, United Kingdom.
Elife ; 102021 10 12.
Article en En | MEDLINE | ID: mdl-34636321
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Eliminación de Gen / Neoplasias de Células Escamosas / Ubiquitina Tiolesterasa / Proteínas de Unión al ADN / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Idioma: En Revista: Elife Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Factores de Transcripción / Eliminación de Gen / Neoplasias de Células Escamosas / Ubiquitina Tiolesterasa / Proteínas de Unión al ADN / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Idioma: En Revista: Elife Año: 2021 Tipo del documento: Article