Clarifying the molecular mechanism of tomentosin­induced antiproliferative and proapoptotic effects in human multiple myeloma via gene expression profile and genetic interaction network analysis.

Virdis, Patrizia; Migheli, Rossana; Bordoni, Valentina; Fiorentino, Francesco Paolo; Sanna, Luca; Marchesi, Irene; Pintore, Giorgio; Galleri, Grazia; Muroni, Maria Rosaria; Bagella, Luigi; Fozza, Claudio; De Miglio, Maria Rosaria; Podda, Luigi

Clarifying the molecular mechanism of tomentosininduced antiproliferative and proapoptotic effects in human multiple myeloma via gene expression profile and genetic interaction network analysis.

Virdis, Patrizia; Migheli, Rossana; Bordoni, Valentina; Fiorentino, Francesco Paolo; Sanna, Luca; Marchesi, Irene; Pintore, Giorgio; Galleri, Grazia; Muroni, Maria Rosaria; Bagella, Luigi; Fozza, Claudio; De Miglio, Maria Rosaria; Podda, Luigi.

Afiliación

Virdis P; Department of Medical, Surgical and Experimental Sciences, University of Sassari, I07100 Sassari, Sardinia, Italy.
Migheli R; Department of Medical, Surgical and Experimental Sciences, University of Sassari, I07100 Sassari, Sardinia, Italy.
Bordoni V; Department of Biomedical Sciences, University of Sassari, I07100 Sassari, Sardinia, Italy.
Fiorentino FP; Kitos Biotech Srls, Porto Conte Ricerche, I07100 Sassari, Sardinia, Italy.
Sanna L; Department of Medical, Surgical and Experimental Sciences, University of Sassari, I07100 Sassari, Sardinia, Italy.
Marchesi I; Kitos Biotech Srls, Porto Conte Ricerche, I07100 Sassari, Sardinia, Italy.
Pintore G; Department of Chemistry and Pharmacy, University of Sassari, I07100 Sassari, Sardinia, Italy.
Galleri G; Department of Medical, Surgical and Experimental Sciences, University of Sassari, I07100 Sassari, Sardinia, Italy.
Muroni MR; Department of Medical, Surgical and Experimental Sciences, University of Sassari, I07100 Sassari, Sardinia, Italy.
Bagella L; Department of Biomedical Sciences, University of Sassari, I07100 Sassari, Sardinia, Italy.
Fozza C; Department of Medical, Surgical and Experimental Sciences, University of Sassari, I07100 Sassari, Sardinia, Italy.
De Miglio MR; Department of Medical, Surgical and Experimental Sciences, University of Sassari, I07100 Sassari, Sardinia, Italy.
Podda L; Department of Medical, Surgical and Experimental Sciences, University of Sassari, I07100 Sassari, Sardinia, Italy.

Int J Mol Med ; 48(6)2021 12.

Article en En | MEDLINE | ID: mdl-34643251

Asunto(s)

Antineoplásicos Fitogénicos/farmacología; Apoptosis/efectos de los fármacos; Lactonas/farmacología; Mieloma Múltiple/tratamiento farmacológico; Mieloma Múltiple/genética; Sesquiterpenos/farmacología; Apoptosis/genética; Ciclo Celular/efectos de los fármacos; Línea Celular Tumoral; Ensayos de Selección de Medicamentos Antitumorales; Perfilación de la Expresión Génica; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Mieloma Múltiple/patología; Mapas de Interacción de Proteínas/efectos de los fármacos; Mapas de Interacción de Proteínas/genética; Sesquiterpenos/química

Palabras clave

DNA damageinducible transcript 3 protein; ProteinProtein Interaction network; apoptosis; cyclic AMPdependent transcription factor ATF4; cytotoxicity; gene expression profiling; multiple myeloma; tomentosin

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Apoptosis / Lactonas / Mieloma Múltiple / Antineoplásicos Fitogénicos Tipo de estudio: Prognostic_studies Idioma: En Revista: Int J Mol Med Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2021 Tipo del documento: Article

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