Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation.

Zebley, Caitlin C; Abdelsamed, Hossam A; Ghoneim, Hazem E; Alli, Shanta; Brown, Charmaine; Haydar, Dalia; Mi, Tian; Harris, Tarsha; McGargill, Maureen A; Krenciute, Giedre; Youngblood, Ben

Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation.

Zebley, Caitlin C; Abdelsamed, Hossam A; Ghoneim, Hazem E; Alli, Shanta; Brown, Charmaine; Haydar, Dalia; Mi, Tian; Harris, Tarsha; McGargill, Maureen A; Krenciute, Giedre; Youngblood, Ben.

Afiliación

Zebley CC; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; St. Jude Graduate School of Biomedical Sciences, St. Jude Children's Research Hospit
Abdelsamed HA; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ghoneim HE; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Alli S; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Brown C; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Haydar D; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Mi T; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Harris T; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
McGargill MA; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Krenciute G; Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Youngblood B; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: benjamin.youngblood@stjude.org.

Cell Rep ; 37(2): 109796, 2021 10 12.

Article en En | MEDLINE | ID: mdl-34644568

Asunto(s)

Linfocitos T CD8-positivos/efectos de los fármacos; Diferenciación Celular/efectos de los fármacos; Metilación de ADN/efectos de los fármacos; Proteínas de Unión al ADN/metabolismo; Dioxigenasas/metabolismo; Interferón gamma/metabolismo; Interleucina-12/farmacología; Coriomeningitis Linfocítica/enzimología; Células T de Memoria/efectos de los fármacos; Animales; Linfocitos T CD8-positivos/enzimología; Linfocitos T CD8-positivos/inmunología; Linfocitos T CD8-positivos/virología; Proliferación Celular/efectos de los fármacos; Células Cultivadas; Proteínas de Unión al ADN/genética; Dioxigenasas/genética; Modelos Animales de Enfermedad; Humanos; Memoria Inmunológica/efectos de los fármacos; Interferón gamma/genética; Coriomeningitis Linfocítica/genética; Coriomeningitis Linfocítica/inmunología; Virus de la Coriomeningitis Linfocítica/inmunología; Virus de la Coriomeningitis Linfocítica/patogenicidad; Células T de Memoria/enzimología; Células T de Memoria/inmunología; Células T de Memoria/virología; Ratones Endogámicos C57BL; Ratones Noqueados; Prueba de Estudio Conceptual; Transducción de Señal

Palabras clave

cytokines; effector CD8 T cells; epigenetics; inflammation

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Interferón gamma / Interleucina-12 / Linfocitos T CD8-positivos / Metilación de ADN / Dioxigenasas / Proteínas de Unión al ADN / Células T de Memoria / Coriomeningitis Linfocítica Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Rep Año: 2021 Tipo del documento: Article

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