Synthesis of PF-6870961, a major hydroxy metabolite of the novel ghrelin receptor inverse agonist PF-5190457.

Sulima, Agnieszka; Akhlaghi, Fatemeh; Leggio, Lorenzo; Rice, Kenner C

Sulima, Agnieszka; Akhlaghi, Fatemeh; Leggio, Lorenzo; Rice, Kenner C.

Afiliación

Sulima A; Medication Development Program, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human S
Akhlaghi F; Clinical Pharmacokinetics Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, University of Rhode Island Kingston, RI, United States.
Leggio L; Clinical Psychoneuroendocrinology and Neuropsychopharmacology Section, Translational Addiction Medicine Branch, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 251 Bayview Boulevard, Balt
Rice KC; Medication Development Program, Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human S

Bioorg Med Chem ; 50: 116465, 2021 11 15.

Article en En | MEDLINE | ID: mdl-34662828

Asunto(s)

Alcoholismo/tratamiento farmacológico; Indenos/farmacología; Pirimidinas/farmacología; Receptores de Ghrelina/agonistas; Tiazoles/farmacología; Alcoholismo/metabolismo; Azetidinas/química; Azetidinas/farmacología; Relación Dosis-Respuesta a Droga; Humanos; Indenos/síntesis química; Indenos/química; Estructura Molecular; Pirimidinas/síntesis química; Pirimidinas/química; Receptores de Ghrelina/metabolismo; Compuestos de Espiro/química; Compuestos de Espiro/farmacología; Relación Estructura-Actividad; Tiazoles/síntesis química; Tiazoles/química

Palabras clave

Alcohol use disorder (AUD); Characterization; Hydroxy metabolite PF-6870961; PF-5190457; Synthesis

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Pirimidinas / Tiazoles / Alcoholismo / Receptores de Ghrelina / Indenos Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google