Marker chromosome 1q+ in acute lymphocytic leukemia.
Cancer Genet Cytogenet
; 24(2): 251-5, 1987 Feb.
Article
en En
| MEDLINE
| ID: mdl-3466676
ABSTRACT
This paper presents the results of a cytogenetic analysis on a patient with acute lymphocytic leukemia (ALL) type L2 according to the FAB classification. Of the metaphases examined, 69.3% belong to the aberrant clone of pseudodiploid karyotype. Marker chromosome 14q+ has been identified in all the cells of the clone. Duplication was found in 30% of the metaphases, and in 15% triplication of the proximal segment of the long arm of chromosome #1 (q11-q21). In one metaphase the long arm of chromosome #1 is made up of segment q11-q21 four times repeated. Aberrations of chromosome #1 support the idea that heterochromatic region may be related to the higher degree of the cell malignity.
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Base de datos:
MEDLINE
Asunto principal:
Cromosomas Humanos Par 1
/
Leucemia Linfoide
/
Marcadores Genéticos
/
Aberraciones Cromosómicas
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
1987
Tipo del documento:
Article