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Outcomes of Abrupt Switch to Bevacizumab of Patients Undergoing Aflibercept Intravitreal Injections for Neovascular Age-Related Macular Degeneration in a Tertiary Center in Lombardy, Italy: A Real-Life Retrospective Analysis.
Randazzo, Alessandro; Raimondi, Raffaele; Fossati, Giovanni; Romano, Mary; Sorrentino, Tania; Castellani, Carlo; Rossi, Costanza; Cancian, Giuseppe; Vinciguerra, Paolo.
Afiliación
  • Randazzo A; IRCCS Humanitas Research Hospital, Eye Center, Via Manzoni 56, 20089 Rozzano, Italy.
  • Raimondi R; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Milan, Italy.
  • Fossati G; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Milan, Italy.
  • Romano M; IRCCS Humanitas Research Hospital, Eye Center, Via Manzoni 56, 20089 Rozzano, Italy.
  • Sorrentino T; Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania Luigi Vanvitelli, Neaples, Italy.
  • Castellani C; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Milan, Italy.
  • Rossi C; IRCCS Humanitas Research Hospital, Eye Center, Via Manzoni 56, 20089 Rozzano, Italy.
  • Cancian G; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Milan, Italy.
  • Vinciguerra P; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Milan, Italy.
J Ophthalmol ; 2021: 7940297, 2021.
Article en En | MEDLINE | ID: mdl-34676113
PURPOSE: To assess real-life anatomical and functional outcomes of switch to bevacizumab in patients undergoing aflibercept intravitreal injections for nAMD. METHODS: Retrospective chart review of all patients diagnosed with nAMD and undergoing intravitreal injections of aflibercept who switched to bevacizumab after the resolution XI/1986 of Lombardy Region. RESULTS: Among 128 patients undergoing intravitreal injections, a total of 29 eyes of 29 patients met all inclusion criteria and were included in the statistical analysis. Best corrected visual acuity and central macular thickness did not change significantly (p > 0.05) between baseline, after the loading phase, and at the last follow-up. CONCLUSION: Switching to bevacizumab has been safe and efficacious in patients responding to the loading phase. According to our results, the restrictions imposed by Lombardy Region did not cause any harm to patients undergoing intravitreal anti-VEGF injections.

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: J Ophthalmol Año: 2021 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: J Ophthalmol Año: 2021 Tipo del documento: Article