Rutaecarpine, an Alkaloid from <i>Evodia rutaecarpa</i>, Can Prevent Platelet Activation in Humans and Reduce Microvascular Thrombosis in Mice: Crucial Role of the PI3K/Akt/GSK3ß  Signal Axis through a Cyclic Nucleotides/VASP-Independent Mechanism.

Huang, Chun-Jen; Huang, Wei-Chieh; Lin, Wei-Ting; Shu, Lan-Hsin; Sheu, Joen-Rong; Tran, Oanh-Thi; Hsia, Chih-Wei; Jayakumar, Thanasekaran; Bhavan, Periyakali Saravana; Hsieh, Cheng-Ying; Chang, Chao-Chien

Rutaecarpine, an Alkaloid from Evodia rutaecarpa, Can Prevent Platelet Activation in Humans and Reduce Microvascular Thrombosis in Mice: Crucial Role of the PI3K/Akt/GSK3ß Signal Axis through a Cyclic Nucleotides/VASP-Independent Mechanism.

Huang, Chun-Jen; Huang, Wei-Chieh; Lin, Wei-Ting; Shu, Lan-Hsin; Sheu, Joen-Rong; Tran, Oanh-Thi; Hsia, Chih-Wei; Jayakumar, Thanasekaran; Bhavan, Periyakali Saravana; Hsieh, Cheng-Ying; Chang, Chao-Chien.

Afiliación

Huang CJ; Department of Anesthesiology and Integrative Research Center for Critical Care, Wan Fang Hospital, Taipei Medical University, Taipei 110, Taiwan.
Huang WC; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Lin WT; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Shu LH; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Sheu JR; Department of Nutrition, Chung Shan Medical University, Taichung 402, Taiwan.
Tran OT; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Hsia CW; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Jayakumar T; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Bhavan PS; International Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Hsieh CY; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chang CC; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.

Int J Mol Sci ; 22(20)2021 Oct 15.

Article en En | MEDLINE | ID: mdl-34681769

Asunto(s)

Alcaloides Indólicos/farmacología; Activación Plaquetaria/efectos de los fármacos; Quinazolinas/farmacología; Trombosis/prevención & control; Alcaloides/química; Alcaloides/farmacología; Animales; Moléculas de Adhesión Celular/metabolismo; Células Cultivadas; Evodia/química; Glucógeno Sintasa Quinasa 3 beta/metabolismo; Humanos; Alcaloides Indólicos/aislamiento & purificación; Alcaloides Indólicos/uso terapéutico; Masculino; Ratones; Ratones Endogámicos ICR; Proteínas de Microfilamentos/metabolismo; Nucleótidos Cíclicos/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Fosfoproteínas/metabolismo; Extractos Vegetales/química; Extractos Vegetales/farmacología; Agregación Plaquetaria/efectos de los fármacos; Proteínas Proto-Oncogénicas c-akt/metabolismo; Quinazolinas/aislamiento & purificación; Quinazolinas/uso terapéutico; Quinolinas/química; Quinolinas/farmacología; Transducción de Señal/efectos de los fármacos; Trombosis/metabolismo; Trombosis/patología

Palabras clave

MAPK; PI3K/Akt/GSK3ß; VASP; cyclic nucleotide; human platelets; hydroxyl radical; microvascular thrombosis; rutaecarpine

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Quinazolinas / Trombosis / Activación Plaquetaria / Alcaloides Indólicos Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article

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