The Rapidly Expanding Nexus of Immunoglobulin G N-Glycomics, Suboptimal Health Status, and Precision Medicine.
Exp Suppl
; 112: 545-564, 2021.
Article
en En
| MEDLINE
| ID: mdl-34687022
ABSTRACT
Immunoglobulin G is a prevalent glycoprotein, whose downstream immune responses are partially mediated by the N-glycans within the fragment crystallisable domain. Collectively termed the N-glycome, it is considered a complex intermediate phenotype an amalgamation of genetic predisposition, environmental exposure, and health behaviours over the life-course. Thus, the immunoglobulin G N-glycome may provide an indication of health status on the spectrum from health to disease and infirmary. Although variability exists within and between populations, composition of the immunoglobulin G N-glycome remains stable over short periods of time. This underscores the potential of harnessing the immunoglobulin G N-glycome as an ideal tool for preclinical disease risk prediction, stratification, and prognosis through the development of precise dynamic biomarkers.
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1
Base de datos:
MEDLINE
Asunto principal:
Inmunoglobulina G
/
Glicómica
Tipo de estudio:
Prognostic_studies
Idioma:
En
Revista:
Exp Suppl
Año:
2021
Tipo del documento:
Article