Structure of the Streptococcus pyogenes NAD<sup>+</sup> Glycohydrolase Translocation Domain and Its Essential Role in Toxin Binding to Oropharyngeal Keratinocytes.

Velarde, Jorge J; Piai, Alessandro; Lichtenstein, Ian J; Lynskey, Nicola N; Chou, James J; Wessels, Michael R

Structure of the Streptococcus pyogenes NAD⁺ Glycohydrolase Translocation Domain and Its Essential Role in Toxin Binding to Oropharyngeal Keratinocytes.

Velarde, Jorge J; Piai, Alessandro; Lichtenstein, Ian J; Lynskey, Nicola N; Chou, James J; Wessels, Michael R.

Afiliación

Velarde JJ; Division of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Piai A; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Lichtenstein IJ; Division of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Lynskey NN; Division of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Chou JJ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Wessels MR; Division of Infectious Diseases, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.

J Bacteriol ; 204(1): e0036621, 2022 01 18.

Article en En | MEDLINE | ID: mdl-34694903

Asunto(s)

Queratinocitos/fisiología; NAD+ Nucleosidasa/metabolismo; Orofaringe/citología; Streptococcus pyogenes/enzimología; Sustitución de Aminoácidos; Adhesión Bacteriana; Proteínas Bacterianas/metabolismo; Toxinas Bacterianas/metabolismo; Línea Celular; Humanos; Modelos Moleculares; NAD+ Nucleosidasa/química; NAD+ Nucleosidasa/genética; Unión Proteica; Conformación Proteica; Dominios Proteicos; Transporte de Proteínas; Streptococcus pyogenes/genética; Streptococcus pyogenes/metabolismo; Estreptolisinas/metabolismo

Palabras clave

NADase; NMR spectroscopy; Streptococcus pyogenes; cell binding; nuclear magnetic resonance; toxin; toxins

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Orofaringe / Streptococcus pyogenes / Queratinocitos / NAD/ Nucleosidasa Tipo de estudio: Prognostic_studies Idioma: En Revista: J Bacteriol Año: 2022 Tipo del documento: Article

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