Repression precedes independent evolutionary gains of a highly specific gene expression pattern.
Cell Rep
; 37(4): 109896, 2021 10 26.
Article
en En
| MEDLINE
| ID: mdl-34706247
ABSTRACT
Highly specific expression patterns can be caused by the overlapping activities of activator and repressor sequences in enhancers. However, few studies illuminate how these sequences evolve in the origin of new enhancers. Here, we show that expression of the bond gene in the semicircular wall epithelium (swe) of the Drosophila melanogaster male ejaculatory bulb (EB) is controlled by an enhancer consisting of an activator region that requires Abdominal-B driving expression in the entire EB and a repressor region that restricts this expression to the EB swe. Although this expression pattern is independently gained in the distantly related Scaptodrosophila lebanonensis and does not require Abdominal-B, we show that functionally similar repressor sequences are present in Scaptodrosophila and also in species that do not express bond in the EB. We suggest that during enhancer evolution, repressor sequences can precede the evolution of activator sequences and may lead to similar but independently evolved expression patterns.
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MEDLINE
Asunto principal:
Acetiltransferasas
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Regulación de la Expresión Génica
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Elementos de Facilitación Genéticos
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Evolución Molecular
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Proteínas de Drosophila
Idioma:
En
Revista:
Cell Rep
Año:
2021
Tipo del documento:
Article