Pathogenicity of the MAGE family.

Li, Sanyan; Shi, Xiang; Li, Jingping; Zhou, Xianrong

Li, Sanyan; Shi, Xiang; Li, Jingping; Zhou, Xianrong.

Afiliación

Li S; Department of Pathology, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China.
Shi X; Department of Pathology, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China.
Li J; Department of Respiratory Medicine, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China.
Zhou X; Department of Pathology, Qianjiang Central Hospital, Qianjiang, Hubei 433100, P.R. China.

Oncol Lett ; 22(6): 844, 2021 Dec.

Article en En | MEDLINE | ID: mdl-34733362

ABSTRACT

ABSTRACT

The melanoma antigen gene (MAGE) protein family is a group of highly conserved proteins that share a common homology domain. Under normal circumstances, numerous MAGE proteins are only expressed in reproduction-related tissues; however, abnormal expression levels are observed in a variety of tumor tissues. The MAGE family consists of type I and II proteins, several of which are cancer-testis antigens that are highly expressed in cancer and serve a critical role in tumorigenesis. Therefore, this review will use the relationship between MAGEs and tumors as a starting point, focusing on the latest developments regarding the function of MAGEs as oncogenes, and preliminarily reveal their possible mechanisms.

Palabras clave

melanoma antigen gene; pathogenicity; tumorigenesis; ubiquitination

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