Ability of the Glasgow Prognostic Score to predict the tolerability and efficacy of platinum-combination chemotherapy among elderly patients with advanced non-small cell lung cancer.
J Med Invest
; 68(3.4): 260-264, 2021.
Article
en En
| MEDLINE
| ID: mdl-34759141
ABSTRACT
Backgroundâ
â
Although platinum-combination chemotherapy is widely used to treat advanced non-small cell lung cancer (NSCLC), not all elderly patients benefit from this regimen. In this retrospective study, we aimed to evaluate whether the Glasgow Prognostic Score (GPS), an indicator of systemic inflammation and malnutrition, could predict the tolerability and efficacy of platinum-combination chemotherapy among elderly patients with NSCLC. Methodsâ
â
The eligibility criteria included patients aged ≥â70 years with NSCLC treated with first-line platinum-combination chemotherapy at Shimane University Hospital between January 2015 and December 2018. Resultsâ
â
Thirty-two patients with NSCLC (median age, 74 years) were included. The GPS scores were 0-1 for 19 patients and 2 for 13 patients. Four chemotherapy cycles were completed by 57.9% and 30.8% of patients in the GPS 0-1 and GPS 2 groups, respectively. The GPS 0-1 group experienced better outcomes than the GPS 2 group (response rateâ
â
26% vs. 15%, Pâ=â0.67â
;â
median progression-free survivalâ
â
4.1 vs. 2.1 months, Pâ=â0.0026â
;â
median overall survivalâ
â
22.8 vs. 9.6 months, Pâ=â0.0092). Conclusionsâ
â
Platinum-combination chemotherapy demonstrated promising efficacy among elderly NSCLC patients with a GPS 0-1. Therefore, GPS may be crucial in determining whether treatments recommended for younger patients are suitable for older patients with NSCLC. J. Med. Invest. 68 260-264, August, 2021.
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Base de datos:
MEDLINE
Asunto principal:
Carcinoma de Pulmón de Células no Pequeñas
/
Neoplasias Pulmonares
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Med Invest
Asunto de la revista:
MEDICINA
Año:
2021
Tipo del documento:
Article