New Heights for ProTides?
J Med Chem
; 64(22): 16422-16424, 2021 11 25.
Article
en En
| MEDLINE
| ID: mdl-34783565
ABSTRACT
In this issue of the Journal of Medicinal Chemistry, Janeba et al. found that the in vitro antiviral activity and selectivity index of the aryloxy phosphoramidate (ProTide) prodrug of the acyclic nucleoside phosphonate tenofovir (tenofovir alafenamide) can be dramatically improved by replacing the aryloxy pro-moiety with an appropriate tyrosine derivative. This Viewpoint highlights the possible impact and ramifications that these findings may have in the development of new ProTides.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Profármacos
/
Organofosfonatos
Idioma:
En
Revista:
J Med Chem
Asunto de la revista:
QUIMICA
Año:
2021
Tipo del documento:
Article