Catalyst-Controlled Regiodivergent Synthesis of α/ß-Dipeptide Derivatives via N-Allylic Alkylation of O-Alkyl Hydroxamates with MBH Carbonates.
Chem Asian J
; 17(1): e202101186, 2022 Jan 03.
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| MEDLINE
| ID: mdl-34811892
ABSTRACT
A controllable and regiodivergent N-allylation reaction involving readily available O-alkyl hydroxamates derived from natural α-amino acids has been developed, allowing regiospecific access to α/ß-dipeptides containing α-unsaturated ß-amino acids moieties in moderate to good yields. The regioselectivity could be conveniently switched by alternation of the catalysts and solvents.
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MEDLINE
Asunto principal:
Compuestos Alílicos
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En
Revista:
Chem Asian J
Año:
2022
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Article