Skin models for cutaneous melioidosis reveal <i>Burkholderia</i> infection dynamics at wound's edge with inflammasome activation, keratinocyte extrusion and epidermal detachment.

Ku, Joanne Wei Kay; Marsh, Supatra Tharinee; Nai, Mui Hoon; Robinson, Kim Samirah; Teo, Daniel Eng Thiam; Zhong, Franklin Lei; Brown, Katherine A; Lim, Thiam Chye; Lim, Chwee Teck; Gan, Yunn-Hwen

Skin models for cutaneous melioidosis reveal Burkholderia infection dynamics at wound's edge with inflammasome activation, keratinocyte extrusion and epidermal detachment.

Ku, Joanne Wei Kay; Marsh, Supatra Tharinee; Nai, Mui Hoon; Robinson, Kim Samirah; Teo, Daniel Eng Thiam; Zhong, Franklin Lei; Brown, Katherine A; Lim, Thiam Chye; Lim, Chwee Teck; Gan, Yunn-Hwen.

Afiliación

Ku JWK; Department of Biochemistry, National University of Singapore, Singapore, Singapore.
Marsh ST; Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
Nai MH; Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
Robinson KS; Skin Research Institute of Singapore (SRIS), Immunos, Singapore.
Teo DET; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Zhong FL; Skin Research Institute of Singapore (SRIS), Immunos, Singapore.
Brown KA; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Lim TC; Cavendish Laboratory, University of Cambridge, Cambridge, UK.
Lim CT; Oden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, TX, USA.
Gan YH; Division of Plastic, Reconstructive &Aesthetic Surgery, National University Health System, Singapore, Singapore.

Emerg Microbes Infect ; 10(1): 2326-2339, 2021 Dec.

Article en En | MEDLINE | ID: mdl-34821529

Asunto(s)

Burkholderia pseudomallei/fisiología; Burkholderia/fisiología; Epidermis/microbiología; Inflamasomas/metabolismo; Queratinocitos/microbiología; Melioidosis/microbiología; Piel/microbiología; Heridas y Lesiones/microbiología; Células Cultivadas; Epidermis/metabolismo; Humanos; Queratinocitos/metabolismo; Melioidosis/metabolismo; Melioidosis/patología; Modelos Biológicos; Piel/metabolismo; Piel/patología; Heridas y Lesiones/metabolismo; Heridas y Lesiones/patología

Palabras clave

Burkholderia; inflammasome; keratinocyte; melioidosis; skin

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piel / Heridas y Lesiones / Queratinocitos / Burkholderia pseudomallei / Burkholderia / Epidermis / Inflamasomas / Melioidosis Idioma: En Revista: Emerg Microbes Infect Año: 2021 Tipo del documento: Article

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