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Heart Mitochondrial Metabolic Flexibility and Redox Status Are Improved by Donkey and Human Milk Intake.
Trinchese, Giovanna; Cimmino, Fabiano; Cavaliere, Gina; Rosati, Luigi; Catapano, Angela; Sorriento, Daniela; Murru, Elisabetta; Bernardo, Luca; Pagani, Luciana; Bergamo, Paolo; Scudiero, Rosaria; Iaccarino, Guido; Greco, Luigi; Banni, Sebastiano; Crispino, Marianna; Mollica, Maria Pina.
Afiliación
  • Trinchese G; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
  • Cimmino F; BAT Centre-Interuniversity Centre for Studies on Bioinspired Agro-Environmental Technology, University of Naples Federico II, 80055 Naples, Italy.
  • Cavaliere G; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
  • Rosati L; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
  • Catapano A; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
  • Sorriento D; BAT Centre-Interuniversity Centre for Studies on Bioinspired Agro-Environmental Technology, University of Naples Federico II, 80055 Naples, Italy.
  • Murru E; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
  • Bernardo L; Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy.
  • Pagani L; Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
  • Bergamo P; Department of Biomedical Sciences, University of Cagliari, 09042 Cagliari, Italy.
  • Scudiero R; Department of Childhood and Developmental Medicine, ASST Fatebenefratelli-Sacco, 20157 Milan, Italy.
  • Iaccarino G; Department of Childhood and Developmental Medicine, ASST Fatebenefratelli-Sacco, 20157 Milan, Italy.
  • Greco L; Institute of Bioscience and Bioresources CNR, IBBR-UOS, 80131 Naples, Italy.
  • Banni S; Department of Biology, University of Naples Federico II, 80126 Naples, Italy.
  • Crispino M; BAT Centre-Interuniversity Centre for Studies on Bioinspired Agro-Environmental Technology, University of Naples Federico II, 80055 Naples, Italy.
  • Mollica MP; Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, Italy.
Antioxidants (Basel) ; 10(11)2021 Nov 13.
Article en En | MEDLINE | ID: mdl-34829678
The biological mechanisms linking nutrition and antioxidants content of the diet with cardiovascular protection are subject of intense investigation. It has been demonstrated that dietary supplementation with cow, donkey or human milk, characterized by distinct nutritional properties, triggers significant differences in the metabolic and inflammatory status through the modulation of hepatic and skeletal muscle mitochondrial functions. Cardiac mitochondria play a key role for energy-demanding heart functions, and their disfunctions is leading to pathologies. Indeed, an altered heart mitochondrial function and the consequent increased reactive oxygen species (ROS) production and inflammatory state, is linked to several cardiac diseases such as hypertension and heart failure. In this work it was investigated the impact of the milk consumption on heart mitochondrial functions, inflammation and oxidative stress. In addition, it was underlined the crosstalk between mitochondrial metabolic flexibility, lipid storage and redox status as control mechanisms for the maintenance of cardiovascular health.
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Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Antioxidants (Basel) Año: 2021 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Idioma: En Revista: Antioxidants (Basel) Año: 2021 Tipo del documento: Article